Genomics/ProteomicsMining the Breast Cancer Proteome for Predictors of Drug Sensitivity
Approximately 20 drugs have been approved by the FDA for breast cancer treatment, yet predictive biomarkers are known for only a few of these.
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Figure 2: Drug sensitivity as a function of HER2 expression. Each point corresponds to a cell line. A. Gefitinib B. Lapatinib. Sensitivity (vertical axis) is the negative common logarithm of GI50, the drug concentration that inhibits proliferation by 50% (ref. 4). The horizontal axis is the common logarithm of the spectral counts, after adding 1 to each value. Red symbols: cell lines that overexpress HER2. Blue symbols: drug-sensitive cell lines that do not overexpress HER2.