Genomics/ProteomicsProteomics Analysis of Brain Meningiomas in Pursuit of Novel Biomarkers of the Aggressive Behavior
The aim of this pilot study was to evaluate the use of advanced proteomics techniques to identify novel protein markers that contribute to the transformation of benign meningiomas to more aggressive and malignant subtypes.
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Figure 1: Histopathological progression of meningiomas from grade I (typical) to grade II (atypical) to grade III (anaplastic) subtypes. As the tumors become increasingly aggressive the cellularity increases, nuclear atypia formation and loss of cytoarchitecture.