Ernst Ruska Prize 2017Cryo-EM structure of haemoglobin at 3.2 Å determined with the Volta phase plate
With the advent of direct electron detectors, the perspectives of cryo-electron microscopy (cryo-EM) have changed in a profound way.
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Figure 5. Validation of water molecules. (a) C2 symmetry reconstruction showing a water molecule density in the same location as observed in a crystal structure (b) (PDB-2DN1). (c,d) Same as (a) overlaid with two conjugate locations in the asymmetric reconstruction.