Cell Damage and DiseaseDouble-Stranded DNA Damage Assessed with Raman Spectroscopy
Double stranded DNA breaks [DSBs] and subsequent repair can correct DNA damage or may mistakenly cause mutations leading to cell damage and disease.
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Figure 3: Three Raman spectra of control and Bleocin™ treated cell DNA after 2 (A) and 4 (B) days. Cell viability: controls were C day 2 (90%), C day 4 (93%), Bleocin™ day 2 (54%), Bleocin™ day 4 (16%). Generally, cells divided after 24h in controls, whereas cell division, based on cell counts, was impaired in Bleocin™ treated samples (not shown). Enhanced 880, 1044, 1084, and 1456 cm-1 peaks are again noted in 2 and 4d Bleocin™ treated cells.