Cell Damage and DiseaseDouble-Stranded DNA Damage Assessed with Raman Spectroscopy
Double stranded DNA breaks [DSBs] and subsequent repair can correct DNA damage or may mistakenly cause mutations leading to cell damage and disease.
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Figure 5: G50μg of total protein extract/lane from C(control) or cells treated with16 μg/ml Bleocin™ for 2 days or 4 days. Samples were separated on a 10% (A, C) or 12% (B) (w/v) SDSLaemmli gel, blotted to nitrocellulose. Blots were reacted with (A) anti-53BP1 (214 Kd), (B) anti-TAp73 (73Kd), or (C) anti–alpha tubulin (50 Kd) antibodies. Data shown is a representative blot from three experiments.