Cell Damage and DiseaseDouble-Stranded DNA Damage Assessed with Raman Spectroscopy
Double stranded DNA breaks [DSBs] and subsequent repair can correct DNA damage or may mistakenly cause mutations leading to cell damage and disease.
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Figure 4: Approximately 1 μg/lane of genomic DNA isolated from Jurkat cells after 2 and 4 days of Bleocin™ treatment. Kilobase markers are indicated with the Hind III ladder. Genomic DNA is largely intact and greater than 24 KB. Lambda Hind III marker was used as a size reference. Slightly more smearing in DNA from cells in the Bleocin™ treatments was observed.